Janet L. Fisher, Ph.D
Postdoctoral: Univ Michigan & Baylor College of Medicine
Ph.D: University of North Carolina - Chapel Hill
M.S.: North Carolina State University
My lab studies the functional properties of ligand-gated ion channels, focusing on GABAA and kainate receptors. These channels are receptors for glutamate and GABA, which are the primary excitatory and inhibitory neurotransmitters in the brain. We study the activity of the receptors by measuring the electrical current that passes through their open channels. The GABAA receptors are responsible for fast inhibitory neurotransmission, and are targets for many common drugs used to treat anxiety, insomnia, and epilepsy. We are interested in learning how changes in the structure of these receptors can affect their function and pharmacology. We also study the kainate type of glutamate receptors. These receptors can play a critical role in the development of epilepsy. Our work focuses on the distinct functional properties associated with different subunits of the kainate receptors.
- Fisher, J.L. (2009) The anticonvulsant stiripentol acts directly on the GABAA receptor as a positive allosteric modulator. Neuropharmacology 56:190-197.
- Mott DD, Rojas A, Fisher JL, Dingledine RJ, Benveniste M (2010) Subunit-specific desensitization of heteromeric kainate receptors. Journal of Physiology, 588:683-700.
- Fisher JL (2011) Interactions between modulators of the GABAA receptor: Stiripentol and benzodiazepines. European Journal of Pharmacology, 654:160-165.
- Bianchi MT, Clark AG, Fisher JL (2011) The wake-promoting neurotransmitter histamine preferentially enhances α4 subunit-containing GABAA receptors, Neuropharmacology, 61:747-752.
- Fisher JL, Mott DD (2011) Distinct Functional Roles of Subunits within the Heteromeric Kainate Receptor, Journal of Neuroscience, 31:17113-17122.
- Alexeev M, Grosenbaugh DK, Mott DD, Fisher JL (2012) The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptors, Neuropharmacology 62:2507-2514.
- Fisher JL, Mott DD (2012) The auxiliary subunits Neto1 and Neto2 reduce voltage-dependent inhibition of recombinant kainate receptors. Journal of Neuroscience 32:12928-12933