James Coleman, adjunct

Professor

Ph.D., 1974 - University of California, Los Angeles

Research Focus:

I am a neuroscientist involved in the study of the organization and development of the auditory system. Of particular recent interest is the examination of the physiological, structural, and behavioral effects of damage to the auditory midbrain and the effects of neural grafting in mediating possible recovery. Physiological measures include recording of auditory brainstem neural activity and monitoring spontaneous and stimulus-drive metabolic activity using immunochemical and autoradiographic procedures. Structural analyses include examination of neural immunostaining for neurotransmitters (e.g., GABA) and membrane associated proteins (e.g., calbindin). Behavioral studies include analysis of auditory response thresholds and stimulus localization in the auditory field. Developmental work focuses upon the pattern of fiber invasion to the immature midbrain and the role of afferent fiber systems in dendritic elaboration and appearance of neurochemical properties. The development of electrophysiological potentials is also studied in the auditory brainstem. I have published a state-of-the-art volume on physiological, structural, and behavioral manifestations of development of mammalian sensory systems.

Recent Publications

• Ross, K. C., C. Conero-Goldberg, Freed, W. J., Waldman, B. C., & J. R. Coleman (2002). Transplantation of M213-20 cells with enhanced GAD67 expression in the inferior colliculus alters audiogenic seizures. Experimental Neurology, 177, 338-340.
• Ross, K. C, J. R. Coleman, & L. S. Jones (2001). Anti-epileptiform effects of audiogenic seizure priming on in vitro kindling in rat hippocampus. Neuroscience Letters, 299, 234-238.
• Coleman, J. R., C. J. Gibson, Fourqurean, G.D., & K. C. Ross (2000). Neural graft modulation of audiogenic seizure susceptibility. Experimental Neurology, 164, 139-144.
• Ross, K. C., & J. R. Coleman (2000). Developmental and genetic audiogenic seizure models: Behavior and biological substrates. Neuroscience and Biobehavioral Reviews, 24, 639-653.
• Coleman, J. R., Ross, K. C., Mullaney, M. M., & Cooper, W. A. (l999). Latency alterations of the auditory brainstem response in audiogenic seizure-prone Long-Evans rats. Epilepsy Research, 33, 31-38.
• Ross, K. C., & Coleman, J. R. (l999). Audiogenic seizures in the developmentally primed Long-Evans rat. Developmental Psychobiology, 34, 303-313.
• Zrull, M. C., & Coleman, J. R. (1997). Effects of tectal grafts on sound localization deficits induced by inferior colliculus lesions in hooded rats. Experimental Neurology, 145, 16-23.