John W. Baynes, Ph.D.
Rank/titles: Carolina Distinguished Professor Emeritus
Postdoctoral: Universities of Pittsburgh and Minnesota
Ph.D.: Johns Hopkins University
MS: Marshall University
BS/BA: Loyola College, Baltimore
Dr. Baynes’ CV
We study the role of chemical modifications of proteins in development of pathology during aging and in age-related diseases, with emphasis on modifications of proteins by carbohydrates and lipids in diabetes and their role in development of diabetic complications: nephropathy, retinopathy and cardiovascular disease. Recent work has focused on succination of proteins, resulting from oxidative and mitochondrial stress in obesity and diabetes. We seek not only to characterize and quantify the modifications on protein, but also to understand their pathological significance and to develop therapeutic inhibitors of these reactions.
- Frizzell N, Thomas SA, Carson JA, Baynes JW. Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity. Biochem J 2012;445:247-54.
- Nagai R, Murray DB, Metz TO, Baynes JW. Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications. Diabetes 2012;61:549-59.
- Merkley ED, Metz TO, Smith RD, Baynes JW, Frizzell N. The Succinated Proteome. Mass Spectrom Rev., 2013, in press.
- Frizzell N, Baynes JW. (2013) Chelation Therapy for Management of Diabetic Complications: A Hypothesis and a Proposal for Clinical Laboratory Assessment of Metal Ion Homeostasis in plasma. Clin Chem Lab Med, in press.
- Frizzell N, Baynes JW. (2013) Chelation therapy: Overlooked in the treatment and prevention of diabetes complications? Fut Med Chem, in press.
- Baynes JW, Dominiczak MH. Textbook of Medical Biochemistry, Elsevier, London. 3nd Edition, 2009; 4th Edition in press, 2014.